EGFR
Clinically RelevantEpidermal growth factor receptor. This gene encodes a transmembrane glycoprotein that is a member of the protein kinase superfamily. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation.
Chromosome
7p11.2
UniProt ID
P00533
Family
Tyrosine Kinase
Overall Druggability Score
0.90
HIGH POTENTIAL
Clinical Progression
Phase I → II → III
Lead Compounds
Clinical Scoring Map
Efficacy
Safety
PK/PD
IP Status
Protein Domain Arch.
Extracellular
Transmembrane
Kinase Domain
Binding Pocket Vol.
742 ų
Metric Comparisons
Pocket Depth88%
Hydrophobicity65%
Enclosure92%
Kinase Family Tree
Phylogenetic Map
Family Members Summary
| Member | Rel. % | Score | Status |
|---|---|---|---|
| HER2 | 82% | 0.86 | DRUGGABLE |
| HER3 | 64% | 0.42 | CHALLENGING |
| HER4 | 59% | 0.55 | ASSESSING |
Functional Similarity Network
EGFR
Similar Gene Rankings
01
MET
Pathway overlap: 88%
0.82
02
FGFR1
Pathway overlap: 74%
0.78
03
IGF1R
Pathway overlap: 61%
0.71
Batch Progress:
Completed: 124 / 500 genes
| Gene | Total Score | Clinical | Structural | Family | Similar | Interpretation |
|---|---|---|---|---|---|---|
| EGFR | 0.90 | 0.95 | 0.88 | 0.64 | 0.32 | HIGH |
| TP53 | 0.52 | 0.82 | 0.14 | 0.44 | 0.68 | MEDIUM |
| BRCA1 | 0.88 | 0.92 | 0.84 | 0.72 | 0.55 | HIGH |
| PTEN | 0.21 | 0.64 | 0.12 | 0.05 | 0.03 | LOW |
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